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Staff Software Engineer, Clinical Genomics

Natera

$145,600 - $182,000
Oct 31, 2025
Remote, US
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Natera is seeking a Staff Software Engineer - Bioinformatics to lead the development of Tertiary Analysis workflows and tools to improve existing processes and systems used for tertiary analysis.

Requirements

  • 10+ years of experience with bioinformatics or software development for Health Care, focusing on clinical sample processing, variant curation and interpretation, annotations and diagnostic report generation.
  • 10+ years of experience in Python development. Java and SpringBoot are a plus.
  • Preferably a full-stack engineer with React and/or Angular experience or knowledge.
  • Able to write and use SQL queries effectively.
  • Experience in working with an agile software development team using test-driven development and unit testing framework.
  • Good understanding of browser rendering behavior and performance.
  • Knowledge in Kafka, REST API design concepts and JSON.

Responsibilities

  • Be part of a software engineering organization (this is not an R&D position), responsible for designing and implementing bioinformatics and full-stack code for tertiary analysis (SOP automation, technical review, variant classification and case review systems)
  • Design and implement Python, Java (Spring), Kafka, React and Angular software components.
  • Analyze and improve existing front-end applications and propose solutions based on technical (software) experience and bioinformatics knowledge.
  • Provide transparency and working progress on deliverables.

Other

  • Engage with cross-functional teams such as Product Management, R&D, software architects, and senior leadership, aiming to improve existing processes and systems used for tertiary analysis.
  • Excellent communication skills.
  • Experience with public domain data sources, e.g. Clinvar, gnomAD preferred.
  • Knowledge of CI/CD pipelines.
  • Excellent organizational and time management skills.