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Staff/Sr. Staff/Principal I Engineer, Bioinformatics Software

PacBio

$170,400 - $293,900
Aug 27, 2025
Menlo Park, CA, US
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PacBio is seeking an experienced Bioinformatics Software Engineer specializing in C++ to develop high-performance on-instrument software tools and algorithms that advance scientific understanding through cutting-edge technologies.

Requirements

  • 5+ years of professional C++ development experience using modern standards.
  • Expert-level understanding of core bioinformatics concepts, particularly in sequence analysis.
  • Proven experience developing complex algorithms with careful consideration of time and space complexity.
  • Proficiency with version control (Git), automated testing, continuous integration, and code review processes.
  • Experience with memory management, multi-threading, and system-level optimization.
  • Familiarity with common bioinformatics file formats (FASTA, FASTQ, SAM/BAM/CRAM, VCF).
  • Demonstrated ability to debug complex software systems and identify performance bottlenecks.

Responsibilities

  • Design and implement efficient bioinformatics algorithms for sequence analysis in modern C++, meeting performance-critical requirements.
  • Profile and optimize code to enhance memory efficiency and computational speed.
  • Develop clean, well-documented APIs and libraries suitable for integration into broader software ecosystems.
  • Collaborate with team members, sharing insights and best practices, and fostering a culture of continuous improvement.
  • Maintain comprehensive and clear documentation covering software design, implementation, and optimization strategies.

Other

  • Master's or Ph.D. in Bioinformatics, Computational Biology, Computer Science, or a related field.
  • Excellent interpersonal, written, and verbal communication skills.
  • This role is not eligible for visa sponsorship.
  • Non-Field Based Employees are required to be onsite Monday-Thursday (Friday work from home).
  • You may be required from time to time to visit and work at PacBio locations.