Revolution Medicines is looking to develop novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. The Translational Sciences team needs to develop and support novel immunofluorescence and histology biomarker assays for RVMD RAS(ON) inhibitors.
Requirements
- Extensive assay development and execution experience in IHC and/or mIF.
- In-depth understanding of Oncology preclinical disease models and relevant signaling pathways.
- Experience analyzing and interpreting image-based data (eg, HALO, VisioPharm, QuPath).
- Experience in spatial transcriptomics and/or pathology experience would be a strong plus
- An understanding of preclinical to clinical translational concepts would be an advantage
Responsibilities
- Onboard new technology capabilities.
- Design and manage experiments in-house, related to the development of novel biomarker assays for oncology pathway inhibitors.
- Analyze and report biomarker data at internal forums.
- Evaluate new technologies related to biomarker assays.
- Develop high-quality protocols, optimize experimental workflows and data outputs to maximize efficiency.
- Keep robust documentation of performed experiments.
- Comply with internal standard operating procedures and other quality criteria, where necessary.
Other
- M.S. in Cancer Biology/Molecular Biology or a related field with 3+ years of industry experience.
- Results-oriented with a strong track record of research productivity as evidenced, for example, by impactful contributions to drug candidate projects and/or high-quality publications.
- Rigorous, quantitative and detail-oriented.
- Thrives in a collaborative team setting and is driven by a desire innovate and contribute in a high energy start-up environment.
- Excellent written and verbal communication skills.
- Demonstrated ability to multi-task, prioritize options, anticipate challenges, and execute on goals as a member of an interdisciplinary team is extremely important.
- Ph.D. in Molecular Biology/Cancer Biology or related field
