Revolution Medicines is looking for an experienced Senior Research Associate to help the Discovery Sciences team accelerate their search for new oncology therapeutics by identifying and developing clinically impactful drugs against frontier targets in oncology.
Requirements
- Hands-on protein biochemistry experience (e.g., characterizing and analyzing protein-ligand or protein-protein interactions).
- Experience with biochemical/biophysical assay development, validation, and troubleshooting.
- Proficiency in execution of in vitro biochemical and biophysical assays suitable for the discovery, validation, or mechanistic characterization of target molecules (ITC, SPR/BLI, TR-FRET, fluorescence polarization, etc.)
- Familiarity with data processing and visualization tools for data analysis and figure generation (e.g., R, Vortex, GraphPad Prism, Genedata Screener, etc).
- Familiarity with automated liquid handling (SPT Dragonfly and/or Mosquito, Agilent Bravo, Tecan).
- Experience with high throughput screening.
- Facile with instrumentation, able to trouble shoot problems and work with engineers to generate successful solutions to technical limitations.
Responsibilities
- Design and execution of lead discovery screening methods and experiments to identify compound hits and advance them through hit-to-lead and lead optimization stages.
- Collaborate within Discovery Science and cross-functionally with Compound Management, Structural Biology, and Biology/Chemistry teams to develop and implement biochemical and biophysical assays for hit identification and lead optimization, evaluating compound potency, selectivity, and mechanism of action, biophysical and biochemical assay development.
- Develop, characterize, and execute novel biochemical and biophysical assays to support screening and preclinical development.
- Generate, manage, evaluate, and maintain critical data in an organized manner and disseminate data broadly to relevant departments.
- Maintain detailed electronic lab notebook entries, draft protocols for experiments, assay data summaries, and manage reagent stocks.
Other
- Communicate scientific progress effectively to Discovery Sciences team and facilitate project execution within established timelines.
- Attention to detail with excellent organizational, experimental data recording, and time management skills.
- Excellent written and verbal communication skills.
- Innovative and flexible team-player with high energy and a demonstrated willingness to learn in a fast-paced environment.
- Rigorous, quantitative, detail-oriented experimentalist with an understanding of statistics.
